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Clinicopathological staging of colorectal cancer: Evolution and consensus-an Australian perspective

Pierre H Chapuis1, Charles Chan, Owen F Dent

  • 1Department of Colorectal Surgery, Concord Hospital and Discipline of Surgery, The University of Sydney, New South Wales, Australia.

Journal of Gastroenterology and Hepatology
|January 5, 2011
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...