Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cilia-independent gas-liquid transport, a third mechanism mediating airway mucus clearance.

The Journal of clinical investigation·2026
Same author

Global warming risks dehydrating and inflaming human airways.

Communications earth & environment·2025
Same author

Enhanced pain relief with guanfacine as an adjuvant for trigeminal nerve blocks: insights from a PheWAS-guided randomized controlled study.

Pain medicine (Malden, Mass.)·2025
Same author

Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019.

Pharmacoepidemiology and drug safety·2025
Same author

Cortisol and testosterone coupling: Enhanced hormone reactivity to intercollegiate athletic competition in women athletes.

Psychoneuroendocrinology·2025
Same author

Providing surgeons with feedback on their patients' postoperative home opioid consumption to limit postsurgical opioid prescribing and reduce unused pills: a pilot randomized clinical trial.

Regional anesthesia and pain medicine·2024

Related Experiment Video

Updated: Jun 5, 2026

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications
14:43

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

Published on: September 23, 2013

Transport effects on surface reaction arrays: biosensor applications.

David A Edwards1

  • 1Department of Mathematical Sciences, University of Delaware, Newark, DE 19716-2553, USA. edwards@math.udel.edu

Mathematical Biosciences
|January 5, 2011
PubMed
Summary

Understanding surface-volume reaction kinetics is vital for biological and industrial processes. A new mathematical model reveals that zone placement along a biosensor channel impacts measurements, quantified by an effective Damköhler number.

More Related Videos

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
15:27

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications
14:43

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

Published on: September 23, 2013

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
15:27

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

Area of Science:

  • Biophysical chemistry
  • Chemical engineering
  • Biosensor technology

Background:

  • Surface-volume reactions are crucial in biological and industrial applications, necessitating kinetic understanding.
  • Advanced biosensors like Flexchip and dotLab enable rate constant measurement and model complex biochemical systems.
  • Cell membranes serve as natural models for systems with multiple reacting zones.

Purpose of the Study:

  • To develop a mathematical model for biosensors with multiple reacting zones.
  • To investigate the influence of transport and zone position on reaction kinetics.
  • To quantify the effect of zone placement using an effective Damköhler number.

Main Methods:

  • Development of a basic unidirectional flow mathematical model.
  • Solving the model for typical experimental parameters using perturbation methods.
  • Analysis of zone placement effects along and across the flow channel.

Main Results:

  • A mathematical model incorporating transport and zone position was developed.
  • The impact of zone placement along the channel was quantified using an effective Damköhler number.
  • Zone placement across the channel was found to have no significant effect on measurements.

Conclusions:

  • Mathematical modeling is essential for understanding biosensor systems with multiple reacting zones.
  • Zone position along the channel is a critical factor influencing reaction kinetics.
  • Biosensor design can be optimized by considering the impact of zone placement on kinetic measurements.