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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
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First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

Ignasi Roca1, Paula Espinal, Sara Martí

  • 1Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, CRESIB, Barcelona, Spain.

Antimicrobial Agents and Chemotherapy
|January 5, 2011
PubMed

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ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...