Related Experiment Video

Updated: Jun 5, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
15:29

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Antimicrobial susceptibility of Brucella melitensis isolates in Peru

Ryan C Maves1, Rosa Castillo, Alfredo Guillen

  • 1Division of Infectious Diseases, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA. Ryan.Maves@med.navy.mil

Antimicrobial Agents and Chemotherapy
|January 5, 2011
PubMed

Insights

Brucellosis treatment in Peru showed all tested bacteria were sensitive to common antibiotics. This suggests drug resistance is not a primary cause of patient relapses in this region.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Brucellosis poses a significant public health challenge in Peru.
  • Brucella melitensis biotype 1 is a common cause of human brucellosis.

Purpose of the Study:

  • To evaluate the antimicrobial susceptibility of Brucella melitensis biotype 1 strains isolated from human cases in Peru.
  • To investigate the potential relationship between antimicrobial resistance and brucellosis relapses.

Main Methods:

  • Antimicrobial susceptibility testing was performed using the Etest method.
  • Minimum Inhibitory Concentrations (MICs) were determined for doxycycline, azithromycin, gentamicin, rifampin, ciprofloxacin, and trimethoprim-sulfamethoxazole.
  • 48 human Brucella melitensis biotype 1 isolates from Peru (2000-2006) were analyzed.

Main Results:

  • All 48 evaluated Brucella melitensis isolates were sensitive to the tested antibiotics.
  • No drug resistance was observed in the isolates during the study period.
  • Brucellosis relapses were not found to be associated with antimicrobial resistance.

Conclusions:

  • The tested Brucella melitensis strains in Peru remained susceptible to key antibiotics between 2000 and 2006.
  • Antimicrobial resistance does not appear to be a major factor contributing to brucellosis relapses in this population.
  • Continued surveillance of antimicrobial susceptibility is important for effective brucellosis management in Peru.

More Related Videos

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...