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["Lupus anticoagulant" in immune hyperthyroidism].

G Schuler1, A Alexopoulos, K Hasler

  • 1Abteilung Klinische Endokrinologie, Medizinische Universitätsklinik und Poliklinik, Freiburg.

Deutsche Medizinische Wochenschrift (1946)
|October 5, 1990
PubMed
Summary
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A woman with autoimmune hyperthyroidism developed blood clotting issues due to acquired inhibitors. These inhibitors affected coagulation factors VIII and IX, impacting blood clotting times.

Area of Science:

  • Hematology
  • Endocrinology
  • Immunology

Background:

  • Autoimmune hyperthyroidism, also known as Basedow disease, can present with various systemic manifestations.
  • Normal blood coagulation is essential for hemostasis, and disruptions can lead to bleeding or thrombotic events.

Observation:

  • A 56-year-old woman with autoimmune hyperthyroidism initially had normal blood coagulation.
  • She subsequently developed a prolonged partial thromboplastin time (PTT) and a reduced prothrombin time (Quick value).

Findings:

  • Coagulation factor VIII activity decreased to 18% and factor IX activity to 16%.
  • These reduced factor levels remained unchanged after the addition of normal plasma, indicating the presence of an acquired inhibitor.
  • The findings suggest an acquired inhibitor of plasmatic coagulation was responsible for the observed hemostatic abnormalities.

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Implications:

  • Acquired coagulation inhibitors, initially termed lupus anticoagulants, can occur in autoimmune diseases beyond lupus erythematosus.
  • This case highlights the importance of investigating coagulation abnormalities in patients with autoimmune conditions.
  • Understanding these inhibitors is crucial for managing hemostatic complications in autoimmune diseases.