Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: 10th anniversary of frontiers in surgery: celebrating progress and envisioning the future of multidisciplinary surgery.

Frontiers in surgery·2026

Same author

Preventing distal junctional kyphosis: Choosing a stable end for the lowest-instrumented vertebra is protective following adult cervical deformity surgery.

Journal of craniovertebral junction & spine·2026

Same author

Outcomes and Challenges of Flap Reconstruction for Pressure Injuries in Clinically Complex Patients.

Journal of clinical medicine·2026

Same author

Short-Term Functional Trajectories After Surgery in Older Adults: National Patterns of Loss and Recovery in 436,471 Patients.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026

Same author

Artificial Intelligence-Based Risk Prediction Models for Complications After Tongue Cancer Surgery.

JAMA otolaryngology-- head & neck surgery·2026

Same author

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery.

Aesthetic plastic surgery·2026

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

Template for skin regeneration.

Ioannis V Yannas¹, Dennis P Orgill, John F Burke

¹Cambridge and Boston, Mass. From the Massachusetts Institute of Technology; Brigham and Women's Hospital, Harvard Medical School; and Massachusetts General Hospital.

Plastic and Reconstructive Surgery

|January 5, 2011

Summary

This summary is machine-generated.

Dermal regeneration template effectively treats large burn areas, reducing scars and contractures. This artificial skin substitute aids reconstructive surgery for optimal healing and function.

More Related Videos

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

Area of Science:

Regenerative medicine
Biomaterials science
Plastic and reconstructive surgery

Background:

Critical care advances in the 1970s enabled survival of severe burn patients.
Lack of dermis in artificial skin led to scarring and contractures.
Physicochemical properties for dermal regeneration have been identified, leading to template development.

Purpose of the Study:

To review the literature on dermal regeneration template (DRT) basic science and clinical applications.
To discuss practical experience with DRT in wound management.
To highlight the role of DRT in modern reconstructive surgery.

Main Methods:

Comprehensive review of peer-reviewed literature on dermal regeneration template.
Analysis of basic science principles governing dermal regeneration.
Inclusion of practical clinical experience with dermal regeneration template.

Main Results:

Dermal regeneration template demonstrates efficacy in treating extensive burn areas.
DRT exhibits scar-reducing and regenerative properties.
Applications include reconstructive burns, scar revisions, contracture treatment, and management of wounds over exposed structures.

Conclusions:

Dermal regeneration template is a valuable addition to plastic surgeons' reconstructive armamentarium.
Further technological advancements may enhance regenerative capacity for improved outcomes.
Optimizing aesthetic and functional results in dermal reconstruction is a key goal.