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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

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N-Butyl-pyridine-4-thio-carboxamide

T Kavitha, C Revathi, M Hemalatha

    Acta Crystallographica. Section E, Structure Reports Online
    |January 5, 2011
    PubMed

    Abstract:

    In the title mol-ecule, C(10)H(14)N(2)S, the n-butyl chain assumes a trans zigzag conformation. The dihedral angle between the pyridine ring and the thio-amide plane is 23.38 (8)°. The mol-ecules in the crystal structure are linked by an inter-molecular N-H⋯N hydrogen bond.

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    Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...

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