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Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
1,3,5-Tris(2H-tetra-zol-5-ylmeth-oxy)-benzene
1Ordered Matter Science Research Center, College of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
Abstract:
The title compound, C(12)H(12)N(12)O(3), was obtained by the hydro-thermal reaction of 1,3,5-tricyano-methoxy-benzene and (CH(3))(3)SiN(3). The mol-ecule is almost planar, with an r.m.s. deviation of 0.0976 Å from the plane through all atoms in the mol-ecule. The three tetra-zole rings make dihedral angles of 13.09 (19), 2.01 (19) and 11.56 (18)° with one another and corresponding angles of 8.66 (17), 5.44 (16) and 3.51 (17)° with the central benzene ring. In the crystal structure, inter-molecular N-H⋯N hydrogen bonds form well separated one-dimensional planar sheets.
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