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Updated: Jun 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
(S)-1-[(S)-4-Benzyl-2-thioxothia-zolidin-3-yl]-3-hydroxy-butan-1-one
Jian-Hong Yang1, Cui-Fen Lu, Zu-Xing Chen
1Key Laboratory of Synthesis and Application of Organic Functional Molecules of the Education Ministry, Hubei University, Wuhan, Hubei 430062, People's Republic of China.
Abstract:
The title compound, C(14)H(17)NO(2)S(2), was synthesized by asymmetric aldol condensation of N-acyl-thia-zolidinethione with acetaldehyde. In the mol-ecule, the thia-zolidine five-membered ring assumes an envelope conformation. Inter-molecular C-H⋯O and intra-molecular O-H⋯O and C-H⋯S hydrogen bonding helps to stabilize the structure.
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