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Related Concept Videos

Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
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Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
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Phase II Reactions: Acetylation Reactions01:24

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
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Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism

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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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Published on: November 23, 2016

Ethyl 2-acetyl-hydrazono-2-phenyl-acetate.

Liang-Zhong Xu1, Xu Yi, Guang-Wei An

  • 1College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
PubMed
Summary

This study details the synthesis of a novel chemical compound, C(12)H(14)N(2)O(3), crucial for producing the herbicide metamitron. Its crystal structure reveals specific molecular orientations and hydrogen bonding interactions.

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Area of Science:

  • Organic Chemistry
  • Crystallography

Background:

  • Metamitron is a widely used herbicide.
  • Efficient synthesis of metamitron requires specific intermediate compounds.

Purpose of the Study:

  • To synthesize and characterize a novel intermediate compound for metamitron production.
  • To elucidate the crystal structure and intermolecular interactions of the synthesized compound.

Main Methods:

  • Chemical synthesis of C(12)H(14)N(2)O(3).
  • X-ray diffraction analysis to determine crystal structure.
  • Analysis of dihedral angles and hydrogen bonding.

Main Results:

  • Successful synthesis of the target compound C(12)H(14)N(2)O(3).
  • The benzene ring exhibits specific dihedral angles (86.3° and 10.0°) relative to the ethyl group and acetyl-imino plane.
  • Crystal structure is stabilized by intermolecular C-H⋯O and N-H⋯O hydrogen bonds.

Conclusions:

  • The synthesized compound serves as a viable intermediate for metamitron synthesis.
  • The determined crystal structure provides insights into molecular packing and interactions.
  • Understanding these structural features can aid in optimizing herbicide synthesis processes.