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Updated: Jun 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2,3,10,11-Tetra-meth-oxy-6,7,14,15-tetra-hydro-6,14-methano-cyclo-octa-[1,2-b;5,6-b']diquinoline
Jason Ashmore1, Roger Bishop, Donald C Craig
1School of Chemistry, University of New South Wales, Sydney, Australia 2052.
Abstract:
The racemic title compound, C(27)H(26)N(2)O(4), crystallizes with its central carbon bridge on a twofold axis. It forms parallel chains of mol-ecules utilizing aryl offset face-face inter-actions with an interplanar distance of about 3.5 Å. These chains associate further by means of pairs of O-CH(2)-H⋯π (with H-ring distances ranging from 2.69 to 2.95 Å) and O-CH(2)-H⋯N motifs. The meth-oxy groups in this structure are coplanar with the aromatic rings to which they are attached. This is recognized as being common behaviour amongst aromatic meth-oxy compounds.
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