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Updated: Jun 5, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-Benzyl-2-(2,4-dichloro-phen-oxy)acetamide
This study details the crystal structure of a novel organic compound, C(15)H(13)Cl(2)NO(2). The research highlights the specific dihedral angle between its aromatic rings and its intermolecular hydrogen bonding in the solid state.
Area of Science:
- Crystallography
- Organic Chemistry
- Solid-State Chemistry
Background:
- Understanding the three-dimensional arrangement of atoms in organic molecules is crucial for predicting their properties and reactivity.
- Intermolecular forces, such as hydrogen bonds, significantly influence crystal packing and material characteristics.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(15)H(13)Cl(2)NO(2).
- To quantify the spatial relationship between the aromatic rings within the molecule.
- To identify and describe the intermolecular interactions present in the crystalline state.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of the crystal structure involved measuring bond lengths, bond angles, and dihedral angles.
- Identification of hydrogen bonding networks through crystallographic data analysis.
Main Results:
- The crystal structure of C(15)H(13)Cl(2)NO(2) was successfully determined.
- A dihedral angle of 27.17(11)° was measured between the two aromatic rings.
- N-H⋯O hydrogen bonds were identified as the primary intermolecular interactions, linking molecules in the crystal lattice.
Conclusions:
- The study provides precise structural information for C(15)H(13)Cl(2)NO(2).
- The observed dihedral angle suggests a specific conformation adopted in the solid state.
- The identified hydrogen bonding pattern is key to the compound's crystal packing and stability.
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