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Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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4-Hydroxy-ethyl-4-methyl-morpholinium chloride.

Wang Mei-Ling1, Zang Hong-Jun, Cheng Bo-Wen

  • 1School of Materials and Chemical Engineering and Key Laboratory of Hollow Fiber Membrane Materials & Membrane Processes, Tianjin Polytechnic University, Tianjin 300160, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
PubMed
Summary
This summary is machine-generated.

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This study details the crystal structure of a novel compound, revealing interconnected cation-anion pairs linked by hydrogen bonds. The morpholine ring adopts a chair conformation, stabilized by various intermolecular forces.

Area of Science:

  • Crystallography
  • Chemical Physics
  • Materials Science

Background:

  • Understanding the intermolecular interactions and crystal packing of organic salts is crucial for predicting their physical properties.
  • Morpholine derivatives are prevalent in pharmaceuticals and organic synthesis, necessitating detailed structural characterization.

Purpose of the Study:

  • To elucidate the crystal structure of the title compound, C(7)H(16)NO(2)(+)·Cl(-).
  • To investigate the role of intermolecular hydrogen bonding in stabilizing the crystal lattice.
  • To determine the conformational preferences of the morpholine ring within the crystal structure.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the three-dimensional arrangement of atoms.
  • Analysis of hydrogen bonding networks, including C-H⋯Cl, O-H⋯Cl, and C-H⋯O interactions.

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  • Conformational analysis of the morpholine ring system.

    • Main Results:

    • The asymmetric unit contains two cation-anion pairs, forming an extended network through weak C-H⋯Cl hydrogen bonds.
    • Each cation engages in extensive hydrogen bonding with surrounding chloride anions.
    • The morpholine ring adopts a stable chair conformation.
    • The crystal structure is further stabilized by O-H⋯Cl and C-H⋯O intermolecular hydrogen bonds.

    Conclusions:

    • The crystal structure of C(7)H(16)NO(2)(+)·Cl(-) is characterized by a robust network of intermolecular hydrogen bonds, primarily C-H⋯Cl interactions.
    • The observed chair conformation of the morpholine ring is a key feature influencing the crystal packing.
    • These findings contribute to the understanding of structure-property relationships in organic salts and morpholine derivatives.