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Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N'-(4-Hydroxy-benzyl-idene)-4-meth-oxybenzohydrazide.
1Department of Chemistry, Huainan Normal College, Huainan 232001, People's Republic of China.
Researchers synthesized a novel organic compound, C(15)H(14)N(2)O(3), using 4-hydroxy-benzaldehyde and 4-methoxy-benzohydrazide. The crystal structure reveals a specific dihedral angle and intermolecular hydrogen bonding, forming a 3D framework.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzaldehyde derivatives are important in organic synthesis.
- Benzohydrazides are key intermediates in various chemical reactions.
Purpose of the Study:
- To synthesize and characterize a novel organic compound.
- To investigate the crystal structure and intermolecular interactions.
Main Methods:
- Synthesis via reaction of 4-hydroxy-benzaldehyde and 4-methoxy-benzohydrazide in methanol.
- X-ray crystallography to determine the crystal structure.
Main Results:
- The compound C(15)H(14)N(2)O(3) was successfully synthesized.
- A dihedral angle of 6.8(1)° between benzene rings was observed.
- The methoxy group exhibited disorder, and molecules formed a 3D framework via hydrogen bonds.
Conclusions:
- The study successfully synthesized and characterized a new organic compound.
- The crystal structure provides insights into molecular conformation and intermolecular forces.
- Hydrogen bonding plays a crucial role in the compound's solid-state structure.
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