Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

IUPAC Nomenclature of Aldehydes

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...

Preparation of 1° Amines: Gabriel Synthesis

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...

Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism

The Wittig reaction, which converts aldehydes or ketones to alkenes using phosphorus ylides, proceeds through a nucleophilic addition‒elimination process.
The reaction begins with the nucleophilic addition between a phosphorus ylide and the carbonyl compound. Due to its carbanionic character, phosphorus ylide acts as a strong nucleophile and attacks the electrophilic carbonyl group. This generates a charge-separated dipolar intermediate called betaine. The negatively charged oxygen atom and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Substituent-modulated excited-state dynamics and solvent-sensitized nanosecond triplet harvesting in donor-acceptor TADF emitters.

Physical chemistry chemical physics : PCCP·2026

Same author

Interfacial impedance engineering in ionic hydrogels for integrated enzymatic and electrophysiological sensing.

Biosensors & bioelectronics·2026

Same author

Novel 2-Anilinoquinazoline derivatives as apoptosis-inducing agents in drug-resistant NSCLC cells: Integrating biological and computational evaluation.

Bioorganic chemistry·2026

Same author

A new anilinoquinazoline derivative, F307 induces autophagy and differential apoptosis in wild-type and mutated-epidermal growth factor receptor non-small cell lung cancer cell lines.

Anti-cancer drugs·2025

Same author

Overcoming EGFR mutation resistance: Dual inhibition strategies using TKIs in non-small cell lung cancer therapy.

European journal of medicinal chemistry·2025

Same author

Microwave-Assisted Buchwald-Hartwig Double Amination: A Rapid and Promising Approach for the Synthesis of TADF Compounds.

ACS omega·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

N-(2-Ethyl-phen-yl)phthalimide.

Yen May Fan¹, Norzalida Zakaria, Azhar Ariffin

¹Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Acta Crystallographica. Section E, Structure Reports Online

|January 5, 2011

Summary

This study describes the crystal structure of a novel organic compound, C(16)H(13)NO(2). The research details the specific spatial arrangement and bond angles within the molecule, contributing to the field of structural chemistry.

More Related Videos

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Published on: November 22, 2016

Production and Testing of Antimicrobial Peptides and Their Mimics

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Related Experiment Videos

Last Updated: Jun 5, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Published on: November 22, 2016

Production and Testing of Antimicrobial Peptides and Their Mimics

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Area of Science:

Crystallography
Organic Chemistry
Structural Analysis

Background:

Understanding molecular geometry is crucial for predicting chemical properties.
Phthalimide derivatives are important in various chemical applications.

Purpose of the Study:

To elucidate the three-dimensional structure of the novel compound C(16)H(13)NO(2).
To analyze the dihedral angle between the phthalimide and benzene ring systems.

Main Methods:

Single-crystal X-ray diffraction analysis was employed.
The crystal structure was solved and refined.

Main Results:

The title compound C(16)H(13)NO(2) was successfully synthesized and characterized.
A dihedral angle of 77.2(1)° was measured between the phthalimide and benzene ring systems.

Conclusions:

The determined molecular structure provides fundamental data for C(16)H(13)NO(2).
This structural information can guide further research into the compound's reactivity and applications.