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1-[1-(4-Nitro-phen-yl)ethyl-idene]thio-semicarbazide
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
Researchers synthesized a novel compound, C(9)H(10)N(4)O(2)S, using 1-(4-nitro-phenyl)ethanone and thiosemicarbazide. The crystal structure reveals intermolecular hydrogen bonding involving amine and nitrile groups.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- Thiosemicarbazides are versatile building blocks in medicinal chemistry.
- Nitro-substituted aromatic ketones are common precursors in organic synthesis.
- Understanding intermolecular interactions is crucial for crystal engineering.
Purpose of the Study:
- To synthesize and characterize a novel compound with the molecular formula C(9)H(10)N(4)O(2)S.
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Chemical synthesis involving the reaction of 1-(4-nitro-phenyl)ethanone and thiosemicarbazide in ethanol.
- Characterization of the compound's crystal structure.
Main Results:
- Successful synthesis of the title compound, C(9)H(10)N(4)O(2)S.
- Identification of weak intermolecular N-H⋯S and N-H⋯O hydrogen bonding interactions in the crystal lattice.
- The hydrogen bonding involves the amine and nitrile functional groups as donors.
Conclusions:
- The synthesized compound exhibits specific intermolecular hydrogen bonding patterns.
- These interactions influence the crystal packing and solid-state properties.
- The study contributes to the understanding of hydrogen bonding in organic crystals.
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