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Updated: Jun 5, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Bis(1,2,3,4-tetra-hydro-quinolin-6-yl)methane
Li Shen1, Qi Liu, Hai-Jun Shen
1Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, People's Republic of China.
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
This study details the crystal structure of a novel organic compound, C(19)H(22)N(2). The molecule features two tetra-hydro-quinoline units connected by a methylene bridge, revealing specific conformational details and dihedral angles between aromatic rings.
Area of Science:
- Crystallography
- Organic Chemistry
- Structural Chemistry
Background:
- Understanding the three-dimensional structure of organic molecules is crucial for predicting their properties and reactivity.
- Tetrahydroquinoline derivatives are important scaffolds in medicinal chemistry and materials science.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(19)H(22)N(2).
- To describe the molecular conformation and intermolecular interactions in the solid state.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed to determine the molecular structure.
- The crystal structure was solved and refined to high accuracy.
Main Results:
- The asymmetric unit contains one half-molecule, with the full molecule possessing twofold rotational symmetry.
- The 1,2,3,4-tetrahydro-quinoline rings adopt a flattened-boat conformation.
- A dihedral angle of 64.03(7)° was measured between the two symmetry-related benzene rings.
Conclusions:
- The study provides precise structural data for C(19)H(22)N(2).
- The observed conformation and symmetry offer insights into the packing and potential properties of this compound.
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