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Updated: Feb 27, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
2-[(3-Bromo-phen-yl)imino-meth-yl]phenol
1Microscale Science Institute, Weifang University, Weifang 261061, People's Republic of China.
Researchers synthesized a novel compound, C(13)H(10)BrNO, by reacting 3-bromo-aniline with 2-hydroxy-benzaldehyde. The molecular structure is stabilized by an intramolecular hydrogen bond, influencing its packing. Keywords: novel compound synthesis, molecular structure, hydrogen bonding.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- 3-bromo-aniline and 2-hydroxy-benzaldehyde are common organic precursors.
- Intramolecular hydrogen bonding plays a crucial role in molecular conformation and crystal packing.
- Understanding the synthesis and structural properties of novel organic compounds is essential for materials science.
Purpose of the Study:
- To synthesize and characterize a novel organic compound with the chemical formula C(13)H(10)BrNO.
- To investigate the molecular structure and crystal packing of the synthesized compound.
- To elucidate the role of intramolecular hydrogen bonding in stabilizing the molecular assembly.
Main Methods:
- The compound was synthesized via the reaction of 3-bromo-aniline with 2-hydroxy-benzaldehyde.
- The reaction was conducted at a temperature of 377 K.
- Molecular structure and packing were analyzed (specific techniques not detailed in abstract).
Main Results:
- The title compound, C(13)H(10)BrNO, was successfully prepared.
- The molecular structure and crystal packing are significantly stabilized by an intramolecular O-H⋯N hydrogen bond.
- This hydrogen bond dictates the compound's supramolecular arrangement.
Conclusions:
- The synthesis of C(13)H(10)BrNO from readily available precursors is demonstrated.
- Intramolecular hydrogen bonding is a key factor governing the stability and structural organization of this novel compound.
- The findings contribute to the understanding of structure-property relationships in organic molecules.
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