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Related Experiment Video

Updated: Jun 5, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
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Benznidazole.

José Lamartine Soares-Sobrinho, Marcílio S S Cunha-Filho, Pedro José Rolim Neto

    Acta Crystallographica. Section E, Structure Reports Online
    |January 5, 2011
    PubMed
    Summary

    The molecular conformation of N-benzyl-2-(2-nitro-imidazol-1-yl)acetamide was analyzed. Crystal packing is stabilized by intermolecular N-H⋯O hydrogen bonds, influencing the compound's structure.

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Molecular Structure

    Background:

    • Understanding molecular conformation is crucial for predicting chemical and physical properties.
    • Nitroimidazole derivatives are significant in medicinal chemistry.

    Purpose of the Study:

    • To determine the three-dimensional structure of N-benzyl-2-(2-nitro-imidazol-1-yl)acetamide.
    • To investigate the intermolecular interactions governing its crystal packing.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was performed.
    • Dihedral angles between planar fragments (imidazole, benzyl, acetamide) were measured.

    Main Results:

    • The conformation is defined by dihedral angles: A/C = 88.17(4)°, B/C = 67.12(5)°, and A/B = 21.11(4)°.

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  • A network of strong intermolecular N-H⋯O hydrogen bonds was observed in the crystal lattice.

    • Conclusions:

    • The specific arrangement of planar groups dictates the molecule's conformation.
    • Intermolecular hydrogen bonding plays a key role in the crystal packing and stability of the nitroimidazole derivative.