N-(2-Benzoyl-4-chloro-phen-yl)-4-chloro-benzene-sulfonamide
Abstract:
The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl-sulfonyl derivative of 2-amino-5-chloro-benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra-molecular N-H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chloro-phenyl groups form intra-molecular and inter-molecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid-centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and inter-molecular inter-actions, respectively.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Related Concept Videos
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...
Nomenclature of Aromatic Compounds with a Single Substituent
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
