Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...

Nomenclature of Aryl and Heterocyclic Amines

Nomenclature of Aryl and Heterocyclic Amines

The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.

Nomenclature of Primary Amines

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.

Basicity of Heterocyclic Aromatic Amines

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).

Five-Membered Heterocyclic Aromatic Compounds: Overview

Five-Membered Heterocyclic Aromatic Compounds: Overview

Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom, respectively.

Physical Properties of Amines

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression.

Neoplasia (New York, N.Y.)·2026

Same author

Advances and challenges in neuroimaging-based pain biomarkers.

Cell reports. Medicine·2024

Same author

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023

Same author

Advancements and challenges in neuromodulation technology: interdisciplinary opportunities and collaborative endeavors.

Science bulletin·2023

Same author

Radial growth responses of three coniferous species to climate change on the southern slope of Funiu Mountains, China.

Ying yong sheng tai xue bao = The journal of applied ecology·2023

Same author

Angioplasty for Supra-Aortic Arterial Lesions from Takayasu Arteritis: Efficacy of Cutting Balloon Angioplasty Versus Conventional Balloon Angioplasty.

Annals of vascular surgery·2023

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

4-Methyl-6-phenyl-pyrimidin-2-amine.

Zhen-Jiang Li¹, Jun-E Huang, A-Lan Meng

¹Qingdao University of Science and Technology, Qingdao 266061, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|January 5, 2011

Summary

Researchers synthesized a novel pyrimidine compound, C(11)H(11)N(3). Its crystal structure reveals two distinct molecular conformations and a 3D network formed by hydrogen bonds.

Area of Science:

Organic Chemistry
Crystallography
Materials Science

Background:

Pyrimidine derivatives are crucial in medicinal chemistry and materials science.
Understanding the structure-property relationships of functionalized pyrimidines is essential for developing new applications.

Purpose of the Study:

To synthesize and characterize a novel functionalized pyrimidine compound, C(11)H(11)N(3).
To investigate the crystal structure and intermolecular interactions of the synthesized compound.

Main Methods:

Chemical synthesis of the title compound C(11)H(11)N(3).
Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.
Analysis of torsion angles and hydrogen bonding patterns.

More Related Videos

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Main Results:

The compound C(11)H(11)N(3) was successfully synthesized.
Two independent molecules with differing aromatic ring twists (29.9(2)° and 45.1(2)°) were observed in the asymmetric unit.
Intermolecular N-H⋯N hydrogen bonds form an extensive three-dimensional network in the crystal packing.

Conclusions:

The study provides detailed structural insights into a novel functionalized pyrimidine.
The observed hydrogen bonding network highlights the potential for supramolecular assembly.
This research contributes to the understanding of pyrimidine derivatives for potential applications in chemistry and materials science.