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Updated: Jun 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
(S)-Ethyl 1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazoline-1-carboxyl-ate
Abstract:
The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazol-in-1-carboxylic acid in the presence of HCl/EtOH. In the mol-ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-membered ring shows a typical envelope conformation. Inter-molecular C-H⋯N hydrogen bonding helps to stabilize the crystal structure.
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