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Preparation and Reactions of Sulfides

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...

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(E)-3,4-Dihydroxy-benzaldehyde 4-ethyl-thio-semicarbazone.

Safa'a Fares Kayed, Yang Farina, Ibrahim Baba

Acta Crystallographica. Section E, Structure Reports Online

|January 5, 2011

Summary

This study details the synthesis and crystal structure of a novel thiosemicarbazone derivative. The molecule exhibits an E configuration, planarity, and forms extensive hydrogen bonds in its crystal lattice.

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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

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Published on: June 20, 2014

Area of Science:

Organic Chemistry
Crystallography
Supramolecular Chemistry

Background:

Thiosemicarbazone derivatives are known for diverse biological activities.
Understanding the structure-activity relationship requires detailed crystallographic analysis.

Purpose of the Study:

To synthesize a new thiosemicarbazone compound.
To elucidate its molecular and crystal structure using X-ray diffraction.
To investigate intermolecular interactions within the crystal.

Main Methods:

Chemical synthesis via condensation reaction.
Single-crystal X-ray diffraction analysis.
Analysis of molecular geometry and hydrogen bonding networks.

Main Results:

Successful synthesis of the target compound C(10)H(13)N(3)O(2)S.
Determination of the E configuration around the C=N bond.
Identification of molecular planarity and an intramolecular N-H⋯N hydrogen bond.
Observation of extensive intermolecular O-H⋯O, O-H⋯S, N-H⋯S, and weak C-H⋯O, S⋯O interactions forming sheets.

Conclusions:

The synthesized thiosemicarbazone derivative possesses a planar structure stabilized by intramolecular hydrogen bonding.
The crystal packing is dominated by a robust network of intermolecular hydrogen bonds and other interactions.
This structural characterization provides a foundation for further studies on its properties.