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Updated: Jun 5, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
3-Hydr-oxy-7,8-dimethoxy-quinolin-2(1H)-one
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
This study reveals the crystal structure of C(11)H(11)NO(4), highlighting intramolecular hydrogen bonding that forms a planar ring. Molecules further assemble into dimers through intermolecular hydrogen bonds.
Area of Science:
- Crystallography
- Molecular Chemistry
- Supramolecular Chemistry
Background:
- Understanding molecular interactions is key in crystal engineering.
- Hydrogen bonding plays a crucial role in molecular assembly and material properties.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(11)H(11)NO(4).
- To investigate the role of hydrogen bonding in the compound's solid-state organization.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding networks (intramolecular and intermolecular) was performed.
Main Results:
- The crystal structure features intramolecular O-H⋯O hydrogen bonding, forming a planar five-membered ring.
- This ring is nearly coplanar with the quinoline group of the molecule.
- Intermolecular N-H⋯O hydrogen bonds facilitate the formation of centrosymmetric dimers.
Conclusions:
- The crystal packing of C(11)H(11)NO(4) is dictated by a combination of intramolecular and intermolecular hydrogen bonding.
- The observed hydrogen bonding patterns contribute to the formation of a stable supramolecular architecture.
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