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Updated: Jun 5, 2026
11:45
Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
N-(2,6-Dimethyl-anilino)-5,6-dihydro-4H-1,3-thia-zin-3-ium chloride monohydrate
Mikelis V Veidis1, Liana Orola, Reinis Arajs
1University of Latvia, Kr. Valdemara 48, Riga, LV 1013, Latvia.
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Abstract:
In the title compound, alternatively called xylazine hydro-chloride monohydrate, C(12)H(17)N(2)S(+)·Cl(-)·H(2)O, the six-membered thia-zine ring is in a half-chair conformation. In the crystal structure, six component centrosymmetric clusters are formed via inter-molecular O-H⋯Cl, N-H⋯O and N-H⋯Cl hydrogen bonds involving xylazine cations, chloride anions and water mol-ecules.
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Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
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01:07Acid Halides to Amides: Aminolysis
Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
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