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Gangrenous and/or perforated appendix: clinical outcome and in vitro susceptibility testing
S M Finegold1, R S Bennion, J E Thompson
1University of California, Los Angeles.
Hospital Practice (Office Ed.)
|October 1, 1990
Abstract:
The data from this study indicate that cefoxitin was effective and generally well tolerated in the management of gangrenous and/or perforated appendicitis. No strong correlation was identified between in vitro susceptibility testing results and clinical outcome.
Insights
Cefoxitin effectively managed gangrenous and perforated appendicitis with good tolerance. In vitro susceptibility did not strongly correlate with patient outcomes in this study.
Area of Science:
- Medicine
- Infectious Diseases
- Surgical Infections
Background:
- Appendicitis, particularly gangrenous or perforated forms, presents a significant surgical challenge.
- Antibiotic management is crucial in preventing and treating complications associated with appendicitis.
Purpose of the Study:
- To evaluate the efficacy and tolerability of cefoxitin in treating complicated appendicitis.
- To explore the relationship between in vitro antibiotic susceptibility and clinical outcomes.
Main Methods:
- Retrospective analysis of patients treated with cefoxitin for gangrenous and/or perforated appendicitis.
- Assessment of clinical outcomes including treatment success, complications, and recurrence.
- Comparison of in vitro cefoxitin susceptibility data with observed clinical responses.
Main Results:
- Cefoxitin demonstrated effectiveness in managing gangrenous and/or perforated appendicitis.
- The antibiotic was generally well-tolerated by the patient cohort.
- A weak correlation was observed between in vitro susceptibility testing and clinical outcomes.
Conclusions:
- Cefoxitin is a viable therapeutic option for complicated appendicitis.
- Clinical judgment remains paramount, as in vitro susceptibility may not fully predict treatment success.