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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
t-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one oxime
Abstract:
In the title mol-ecule, C(26)H(28)N(2)O(3), the piperidine ring adopts a chair conformation. The two methoxy-phenyl groups attached to the piperidine ring at positions 2 and 6 have equatorial orientations, and make a dihedral angle of 80.72 (15)°. The benzyl group at position 3 has an equatorial orientation. The oxime group at position 4 has a bi-sectional orientation. The ring of the benzyl group makes dihedral angles of 64.71 (16) and 84.79 (17)° with the two benzene rings. Mol-ecules are linked by inter-molecular N-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds, and C-H⋯π inter-actions. There is also a C-H⋯O intra-molecular inter-action.
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