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Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
1-(2-Methyl-benzo-yl)-3-m-tolyl-thio-urea
Abstract:
The molecule of the title compound, C(16)H(16)N(2)OS, is not planar; the two aromatic rings are inclined to one another by 37.59 (9)°. There are intra-molecular hydrogen bonds between the benzoyl O atom and the H atom of the thio-amide N atom, and between the thio-urea S atom and the H atom of the tolyl group. These hydrogen bonds stabilize the mol-ecule in such a way that the thio-urea group adopts a trans-cis geometry. In the crystal structure, mol-ecules are linked by N-H⋯S inter-molecular hydrogen bonds, forming centrosymmetric dimers.
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