1-[2-(4-Fluoro-benz-yloxy)-2-phenyl-ethyl]-1H-benzimidazole
Abstract:
The asymmetric unit of the title compound, C(22)H(19)FN(2)O, contains two independent mol-ecules. The planar benzimidazole ring systems are oriented with respect to the phen-yl/fluoro-benzene rings at dihedral angles of 31.10 (4)/45.17 (5) and 45.52 (5)/68.63 (5)°, respectively, for the two mol-ecules. In the crystal structure, inter-molecular C-H⋯N and inter-molecular C-H⋯N and C-H⋯F hydrogen bonds link the mol-ecules into a three-dimensional network. There are C-H⋯π contacts between the benzimidazole and fluoro-benzene rings and a π-π contact between the benzimidazole and phenyl ring systems [centroid-centroid distance = 4.575 (1) Å].
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
NMR Spectroscopy of Benzene Derivatives
Nomenclature of Aromatic Compounds with Multiple Substituents
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...
Nomenclature of Aromatic Compounds with a Single Substituent
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene


