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Updated: Jun 5, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-Benzyl-2-(2-chloro-4-methyl-phen-oxy)acetamide
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
This study determined the crystal structure of a small organic molecule, C(16)H(16)ClNO(2). The compound forms hydrogen-bonded chains in its solid state, relevant for molecular interactions.
Area of Science:
- Crystallography
- Structural Chemistry
- Molecular Interactions
Background:
- Understanding interactions between small organic molecules and proteins is crucial in drug discovery and molecular biology.
- Crystal structure determination provides fundamental insights into molecular conformation and intermolecular forces.
Purpose of the Study:
- To elucidate the crystal structure of the organic compound C(16)H(16)ClNO(2).
- To investigate the intermolecular interactions governing the solid-state packing of this molecule.
Main Methods:
- Single-crystal X-ray diffraction was employed for structure determination.
- Analysis of the crystal structure included bond lengths, bond angles, and intermolecular interactions.
Main Results:
- The crystal structure of C(16)H(16)ClNO(2) was successfully determined.
- A dihedral angle of 16.14 (12) ° was observed between the two aromatic rings.
- N-H⋯O hydrogen bonding links molecules into chains along the b axis.
Conclusions:
- The determined crystal structure provides a detailed molecular and supramolecular description.
- The observed hydrogen bonding pattern is a key factor in the compound's crystal packing.
- This structural information can inform studies on molecular recognition and protein-ligand interactions.
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