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Updated: Jun 5, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-Benzyl-2-(2,6-dichloro-phen-oxy)-acetamide
This study determined the crystal structure of a small molecule, revealing its specific molecular arrangement and hydrogen bonding patterns. These findings contribute to understanding small molecule interactions with proteins.
Area of Science:
- Crystallography
- Molecular Biology
- Medicinal Chemistry
Background:
- Understanding small molecule interactions with proteins is crucial for drug discovery.
- Detailed structural information of small molecules provides insights into their biological activity.
Purpose of the Study:
- To determine the crystal structure of the compound C(15)H(13)Cl(2)NO(2).
- To investigate the intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed for structure determination.
- Analysis of the crystal structure revealed key geometric parameters and bonding.
Main Results:
- The crystal structure of C(15)H(13)Cl(2)NO(2) was successfully elucidated.
- A dihedral angle of 40.71° was observed between the two aryl rings.
- Molecules form chains along the b-axis through N-H⋯O hydrogen bonding.
Conclusions:
- The determined crystal structure provides a detailed molecular model.
- The identified hydrogen bonding network is a key feature of the crystal packing.
- This structural data can inform further studies on small molecule-protein interactions.
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