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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Left ventricular function in patients with uncomplicated well-controlled diabetes mellitus

Laura Poantă1, Daniela Fodor, Adriana Albu

  • 1University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, 2nd Department of Internal Medicine, Nicolae Pascaly 9/16, 400431 Cluj-Napoca, Romania. aurapoanta@yahoo.com

Medical Ultrasonography
|January 5, 2011
PubMed

Insights

Early-stage diabetes mellitus (DM) patients often show preclinical signs of cardiac dysfunction. This study found impaired left ventricular filling in asymptomatic individuals with well-controlled DM, highlighting the need for early cardiac monitoring.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Symptomatic heart disease in diabetes mellitus (DM) patients indicates a poor prognosis.
  • Cardiac involvement in DM can precede clinical symptoms, with diastolic dysfunction potentially being the initial stage of diabetic cardiomyopathy.

Purpose of the Study:

  • To assess cardiovascular function in patients with early-stage diabetes mellitus.
  • To identify preclinical cardiac changes in individuals with well-controlled DM.

Main Methods:

  • A cohort of 62 patients (aged 51-65) with well-controlled DM underwent transthoracic echocardiography (TTE).
  • Two-dimensional and pulsed Doppler techniques evaluated left ventricular (LV) systolic and diastolic function.

Main Results:

  • No patients exhibited clinical cardiac signs, ECG, or TTE-detected systolic dysfunction.
  • Significant differences in peak A velocity (P=0.05) and E/A ratio (P=0.01) were observed between DM patients and controls, indicating LV filling impairment.

Conclusions:

  • Preclinical assessment of DM heart disease is crucial.
  • Asymptomatic patients with DM may have treatable diastolic dysfunction and require closer cardiac observation.
Abstract

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