Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coexisting Electronic Smectic Liquid Crystal and Superconductivity in a Si Square-Net Semimetal.

Physical review letters·2026

Same author

Range Modeling and Surveillance of <i>Ornithodoros turicata</i> Ticks: Implications for Detecting African Swine Fever Virus in the United States.

Ecology and evolution·2025

Same author

Evaluating caplacizumab's potential to mitigate thrombosis risk in aortic valve stenosis: a microfluidic and computational approach.

Lab on a chip·2025

Same author

Pilot Evaluation of Functional Lung Imaging via X-Ray Velocimetry for the Assessment of Regional Ventilation in Severe Lung Disease.

Respiration; international review of thoracic diseases·2025

Same author

X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.

Respiratory research·2025

Same author

More accessible functional lung imaging: non-contrast CT-ventilation demonstrates strong association and agreement with PET-ventilation.

Respiratory research·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

Effect of hemodynamic forces on platelet aggregation geometry.

Elham Tolouei¹, Christopher J Butler, Andreas Fouras

¹Fluids Laboratory for Aeronautical and Industrial Research (FLAIR), Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC 3800, Australia.

Annals of Biomedical Engineering

|January 5, 2011

Summary

Platelet aggregation geometry changes with upstream shear rate. Local shear rates on aggregations vary significantly due to geometry, impacting platelet adhesion and aggregation dynamics.

More Related Videos

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Area of Science:

Biomedical Engineering
Fluid Dynamics
Hematology

Background:

Platelet aggregation is crucial for hemostasis and thrombosis.
Understanding the influence of shear forces on platelet aggregation is vital for disease modeling.

Purpose of the Study:

To investigate how shear rate influences platelet aggregation geometry.
To quantify the local shear rate variations on platelet aggregations.

Main Methods:

In vitro experiments were conducted to observe platelet aggregation.
Numerical simulations were used to model blood flow and shear rates.

Main Results:

Upstream shear rate (γ(Pw)) systematically alters mature platelet aggregation geometries.
Local shear rates on aggregation surfaces varied from 0 to 8 times γ(Pw) due to geometric variations.
Growing platelet aggregations exhibit distinct geometries and local shear fields compared to mature ones.

Conclusions:

Platelet aggregation geometry is a key determinant of local shear stress.
Dynamic changes in shear rate and aggregation morphology influence platelet interactions.