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Updated: Jun 5, 2026

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
Cilia in cell signaling and human disorders
Neil A Duldulao1, Jade Li, Zhaoxia Sun
1Department of Genetics, Yale University School of Medicine, 333 Cedar St., SHM I-329A, New Haven, CT 06520, USA.
Abstract:
One of the most widespread cellular organelles in nature is cilium, which is found in many unicellular and multicellular organisms. Formerly thought to be a mostly vestigial organelle, the cilium has been discovered in the past several decades to play critical motile and sensory roles involved in normal organogenesis during development. The role of cilia has also been implicated in an ever increasing array of seemingly unrelated human diseases, including blindness, kidney cysts, neural tube defects and obesity. In this article we review some of the recent developments in research on cilia, and how defects in ciliogenesis and function can give rise to developmental disorders and disease.
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