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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

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Related Experiment Video

Updated: Jun 5, 2026

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Cellular models for disease exploring and drug screening.

Zhi-Kun Li1,2, Qi Zhou3

  • 1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Protein & Cell
|January 5, 2011
PubMed
Summary
This summary is machine-generated.

Drug and disease models, especially induced pluripotent stem cells (iPSC), advance biopharmaceutical research by enabling in vitro disease modeling. This review covers key models and their unique applications.

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Area of Science:

  • Biopharmaceutical research
  • Stem cell technology
  • Disease modeling

Background:

  • Biopharmaceutical development relies heavily on animal and cellular models.
  • Induced pluripotent stem cells (iPSC) offer a revolutionary approach to in vitro disease modeling.
  • These models are crucial for understanding disease mechanisms and testing therapeutics.

Purpose of the Study:

  • To review widely applied drug and disease models in the biopharmaceutical industry.
  • To highlight the specialties and advantages of various modeling systems.
  • To emphasize the role of iPSC technology in advancing disease-specific cell generation.

Main Methods:

  • Literature review of established and emerging drug and disease models.
  • Analysis of the applications and limitations of different model systems.
  • Focus on the capabilities of induced pluripotent stem cells (iPSC) for in vitro studies.

Main Results:

  • Animal and cellular models have distinct roles and limitations.
  • iPSC technology enables the generation of patient-specific cells for disease modeling.
  • Various models offer unique advantages for specific research questions.

Conclusions:

  • The strategic application of diverse models, particularly iPSC, is vital for biopharmaceutical innovation.
  • iPSC technology significantly enhances the potential for in vitro disease modeling.
  • Understanding model specialties optimizes drug discovery and development pipelines.