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Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

Jiyue Zhu1, Yuanjun Zhao, Shuwen Wang

  • 1Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. joz1@psu.edu

Protein & Cell
|January 5, 2011
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
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The chromatin structure, especially...