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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Myocarditis in the setting of RSV bronchiolitis
1University of South Florida College of Medicine, Department of Pediatrics, St. Petersburg, Florida 33701, USA. amenchise@gmail.com
Insights
Fulminant myocarditis is rare in children, but this case highlights respiratory syncytial virus as a potential cause. Early intensive care is crucial for managing this severe heart condition in infants.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Myocarditis in children is typically viral, with enterovirus and adenovirus being common culprits.
- Respiratory syncytial virus (RSV) is a frequent respiratory pathogen in children but rarely linked to myocarditis.
- The exact incidence and prognosis of pediatric myocarditis remain unclear due to diagnostic challenges and varied presentations.
Observation:
- This report details a rare case of fulminant myocarditis in a seven-month-old infant.
- The infant presented with severe bronchiolitis caused by respiratory syncytial virus.
- The clinical presentation underscores a potential, albeit uncommon, association between RSV and severe myocarditis.
Findings:
- The case demonstrates respiratory syncytial virus as a causative agent in fulminant pediatric myocarditis.
- This challenges the general understanding of RSV's limited role in myocarditis.
- The severity of the condition necessitated intensive care unit monitoring.
Implications:
- Highlights the need to consider RSV in the differential diagnosis of pediatric myocarditis, especially in severe cases.
- Emphasizes the importance of prompt pediatric intensive care unit admission for hemodynamic monitoring in suspected pediatric myocarditis.
- Suggests further research into the mechanisms and incidence of RSV-associated myocarditis in children.
Abstract:
Myocarditis in the pediatric population is commonly caused by viral pathogens, notably entero virus and adeno virus. Respiratory syncytial virus, although widespread among this population, is rarely associated with myocarditis. The incidence of myocarditis is unknown due to the variability of clinical presentation and diagnostic limitations. Data regarding prognosis is lacking in children. Patients should be monitored in a pediatric intensive care unit secondary to the risk of hemodynamic compromise. We present the case of fulminant myocarditis in a seven-month old female in the setting of respiratory syncytial virus bronchiolitis.
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