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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jun 5, 2026

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
08:28

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Published on: May 9, 2025

HER2: biology, detection, and clinical implications.

Carolina Gutierrez1, Rachel Schiff

  • 1Baylor College of Medicine, Department of Pathology, One Baylor Plaza, Houston, TX 77030, USA. mgutierr@bcm.edu

Archives of Pathology & Laboratory Medicine
|January 6, 2011
PubMed
Summary

Human Epidermal growth factor Receptor 2 (HER2) is a key driver in 20% of breast cancers. Targeting HER2 in patients with amplified or overexpressed HER2 shows significant mortality reduction.

More Related Videos

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
08:28

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Published on: May 9, 2025

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • HER2 (Human Epidermal growth factor Receptor 2) is an oncogene and membrane tyrosine kinase.
  • Overexpression and gene amplification of HER2 occur in approximately 20% of breast cancers, driving tumor progression.
  • Activated HER2 signaling promotes cell proliferation and inhibits apoptosis, making it a critical factor in tumor development.

Purpose of the Study:

  • To elucidate the fundamental biology of the HER2 signaling network.
  • To review established methods for detecting HER2 in clinical samples.
  • To summarize the clinical outcomes of HER2-targeted therapies.

Main Methods:

  • Literature review of studies indexed in PubMed.
  • Inclusion of relevant older studies identified through the review process.

Main Results:

  • HER2 is integral to a complex signaling network.
  • Gene amplification of HER2 leads to an aggressive breast cancer subtype.
  • Overexpression or amplification of HER2 identifies patients eligible for mortality-reducing therapies.

Conclusions:

  • HER2 plays a crucial role in a specific subset of aggressive breast cancers.
  • Accurate HER2 detection is essential for patient stratification.
  • Targeted therapies directed against HER2 offer significant survival benefits for eligible patients.