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Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

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Updated: Jun 5, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Molecular testing of solid tumors.

Anne Igbokwe1, Dolores H Lopez-Terrada

  • 1Molecular Pathology Laboratory, BloodSource, Mather, CA 95655-4128, USA. Anne.igbokwe@bloodsource.org

Archives of Pathology & Laboratory Medicine
|January 6, 2011
PubMed
Summary

Molecular testing is crucial for diagnosing solid tumors and guiding treatment. Anatomic pathologists need to understand these tests for optimal patient care and consultation.

Area of Science:

  • Oncology
  • Pathology
  • Molecular Diagnostics

Background:

  • Molecular testing is integral to modern anatomic pathology for solid tumors.
  • It aids in diagnosis confirmation, therapy guidance, prognosis assessment, and monitoring treatment response.

Purpose of the Study:

  • To review key molecular biomarkers and assays for common solid tumors.
  • To discuss upcoming molecular diagnostic assays that may become standard of care.

Main Methods:

  • Review of original research articles.
  • Synthesis of review articles.
  • Incorporation of authors' clinical experience.

Main Results:

  • Molecular testing is essential for precise diagnosis and targeted therapy in solid tumors.

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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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  • Knowledge of common molecular tests, their indications, and limitations is vital for pathologists.

    • Conclusions:

    • Molecular testing in anatomic pathology is well-established and expanding.
    • Pathologists must be knowledgeable consultants for clinicians regarding molecular test utilization.