Related Experiment Video

Updated: Jun 5, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Novel molecular therapies in hepatocellular carcinoma

Sandrine Faivre1, Mohamed Bouattour, Eric Raymond

  • 1Department of Medical Oncology, Beaujon/Bichat University Hospital, Assistance Publique-Hôpitaux de Paris, University INSERM U728, Paris 7, Clichy, France.

Liver International : Official Journal of the International Association for the Study of the Liver
|January 6, 2011
PubMed

Insights

Sorafenib is the standard for advanced hepatocellular carcinoma (HCC). Research is exploring new targeted therapies, including small molecules and antibodies, to improve HCC treatment options.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Sorafenib is the established standard of care for advanced hepatocellular carcinoma (HCC).
  • There is ongoing interest in evaluating additional targeted therapies for HCC.
  • Research is exploring earlier stage and adjuvant treatment settings for sorafenib, alone and in combination.

Purpose of the Study:

  • To review current research on targeted therapies for hepatocellular carcinoma (HCC).
  • To highlight small molecules and antibodies with anti-angiogenic and antiproliferative properties under investigation.
  • To discuss the potential of these therapies to expand treatment options for HCC patients.

Main Methods:

  • Literature review of PubMed and MEDLINE databases.
  • Focus on articles published up to September 2010.
  • Identification of preclinical and clinical trials investigating targeted therapies.

Main Results:

  • Several small molecules and humanized antibodies are under investigation.
  • These agents possess anti-angiogenic and antiproliferative properties.
  • Promising results are anticipated from ongoing clinical trials.

Conclusions:

  • Targeted therapies show promise for advancing hepatocellular carcinoma (HCC) treatment.
  • Further clinical trials are expected to yield results within the next decade.
  • Substantial progress in HCC patient management is anticipated in the coming 10 years.

More Related Videos

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...