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Migrating motor complex in colectomized ileo stoma patients
Mark B Hansen1, Lene Wallin, Einar Husebye
1Department of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. mbh@dadlnet.dk
Basic & Clinical Pharmacology & Toxicology
|January 6, 2011
Summary
Serotonin (5-HT) stimulates the migrating motor complex (MMC) in colectomized patients. Ondansetron mitigates this 5-HT effect in patients, offering potential therapeutic insights for ileo stoma management.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Background:
- Colectomized patients with ileo stoma experience disturbed intestinal function, leading to high outputs and malabsorption.
- Serotonin (5-HT) plays a key role in regulating intestinal motor and secretory reflexes via 5-HT(3) and muscarinic receptors.
Purpose of the Study:
- To investigate the effects of 5-hydroxytryptamine (5-HT), ondansetron, and atropine on the migrating motor complex (MMC) in colectomized patients with ileo stoma compared to healthy subjects.
- To assess the impact of these agents on both fasting and stimulated antro-duodeno-jejunal MMC.
Main Methods:
- Manometric recordings were performed in a blinded, age- and gender-matched study.
- Subjects received either a standard meal or intravenous 5-HT, with pre-treatment of saline, ondansetron, or atropine.
- Adverse effects and physiological parameters (blood pressure, heart rate, ECG) were monitored.
Main Results:
- Intravenous 5-HT significantly increased MMC phase III frequency and migration velocity in both patients and healthy subjects.
- Ondansetron attenuated the 5-HT-induced increase in MMC phase III frequency specifically in colectomized patients.
- Atropine reduced the 5-HT-induced MMC phase III frequency in healthy subjects but not in patients.
Conclusions:
- 5-HT acts as a potent stimulator of MMC phase III.
- Ondansetron effectively reduces 5-HT-stimulated MMC phase III in colectomized patients without affecting baseline or postprandial MMC.
- The findings suggest a potential role for ondansetron in managing intestinal dysmotility in colectomized individuals with ileo stoma.
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