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Updated: Jun 5, 2026
08:14
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
Published on: July 31, 2014
History of animal models of stroke
Victoria E O'Collins1, Geoffrey A Donnan, David W Howells
1Department of Medicine, University of Melbourne, Heidelberg, Vic., Australia. ocollins@unimelb.edu.au
Abstract:
Scientists tend to focus on the present and the future. But the practice of experimental stroke is not new. Here, we reflect on the changing landscape of the stroke laboratory over the past 2000-years, focusing on shifts in the rationale for undertaking experiments, the methodologies deployed and the colourful characters involved in this science.