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Updated: Jun 5, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Triggering mechanisms of stent thrombosis
Bastiaan Zwart1, Jochem W van Werkum, Antonius A C M Heestermans
1Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Summary
Potential triggers like time of day, physical exertion, emotional stress, and infection may contribute to stent thrombosis (ST). These factors are particularly relevant in patients experiencing very late ST, highlighting their importance in cardiovascular event management.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Thrombosis Research
Background:
- Stent thrombosis (ST) remains a significant complication following percutaneous coronary intervention (PCI).
- Identifying triggers for ST is crucial for improving patient outcomes and developing preventative strategies.
Purpose of the Study:
- To investigate the role of potential triggers in the onset of stent thrombosis.
- To analyze the association between specific triggers and the timing of ST events.
Main Methods:
- A multicentre observational cohort study included 437 patients with definite ST.
- Validated questionnaires were used to assess triggers: timing, physical activity, emotional stress, and active infection.
- Data from 363 patients were analyzed to identify significant triggers.
Main Results:
- A significant trigger was identified in 22.9% of patients.
- The prevalence of triggers increased with longer time intervals between PCI and ST.
- A peak incidence of ST was observed between 7 am and 12 pm, suggesting circadian variation.
Conclusions:
- Time of day, physical exertion, emotional stress, and infection are important potential triggers for ST.
- These triggering mechanisms are particularly relevant in patients with very late stent thrombosis.
- Understanding these triggers can inform clinical practice and patient management to reduce ST risk.
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