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Related Experiment Video

Updated: Jun 5, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Executive functions in depression: a clinical report.

Rajul Tandon¹, Anand Pratap Singh, P K Sinha

¹RAJUL TANDON, M.D., Research Associate, Department of Psychiatry, C.S.M. Medical University (Upgraded KG. Medical College) Lucknow. rajultandon@yahoo.com.

Indian Journal of Psychiatry

|January 6, 2011

Summary

Depression is linked to cognitive inflexibility and prefrontal dysfunction, as shown by poor performance on the Wisconsin Card Sorting Test (WCST). Cognitive rehabilitation may benefit patients with depression.

Keywords:

Executive function WCST depression

Related Experiment Videos

Last Updated: Jun 5, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Depression is a prevalent mood disorder associated with significant cognitive impairments.
Executive functions, particularly those mediated by the prefrontal cortex, are frequently affected in depression.

Purpose of the Study:

To investigate executive function deficits in patients with depression using the Wisconsin Card Sorting Test (WCST).
To explore the relationship between illness severity and the degree of cognitive impairment in depression.

Main Methods:

Assessment of 50 patients diagnosed with depression and 30 healthy controls.
Utilized clinical rating scales for symptom severity.
Administered the Wisconsin Card Sorting Test (WCST) to evaluate executive functions.

Main Results:

Depressed subjects exhibited significantly poorer performance on the WCST compared to controls.
Impaired WCST performance indicated cognitive inflexibility and prefrontal cortex dysfunction.
Greater severity of depressive illness correlated with more pronounced executive functioning deficits.

Conclusions:

Findings suggest that patients with depression may experience persistent, frontally-based cognitive dysfunction.
The results support the need for incorporating cognitive assessments and rehabilitation strategies into the management of depression.