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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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Related Experiment Video

Updated: Jun 5, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Atorvastatin-induced pancreatitis.

Samir Prajapati1, Samidh Shah, Chetna Desai

  • 1Department of Pharmacology, B. J. Medical College, Ahmedabad, India.

Indian Journal of Pharmacology
|January 6, 2011
PubMed
Summary
This summary is machine-generated.

Atorvastatin, a cholesterol-lowering drug, may cause acute pancreatitis in some patients. Stopping the medication led to complete recovery, suggesting a probable adverse drug reaction.

Keywords:
Adverse drug reactionatorvastatinpancreatitis

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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Drug-induced pancreatitis accounts for 1-2% of all pancreatitis cases.
  • Statins are commonly prescribed for hyperlipidemia.
  • Adverse drug reactions require thorough investigation and reporting.

Purpose of the Study:

  • To report a case of acute pancreatitis potentially induced by atorvastatin.
  • To evaluate the causality of atorvastatin in precipitating pancreatitis.
  • To contribute to the understanding of statin-associated adverse events.

Main Methods:

  • A case study of a 58-year-old male patient with hyperlipidemia.
  • Clinical presentation, laboratory tests (serum lipase), and imaging (CT scan) were used for diagnosis.
  • Causality assessment using Naranjo and WHO-UMC scales.

Main Results:

  • The patient developed acute pancreatitis after 6 months of atorvastatin use.
  • Serum lipase and CT scan confirmed acute pancreatitis.
  • Discontinuation of atorvastatin resulted in complete recovery within 10 days.
  • Causality was assessed as probable for atorvastatin-induced pancreatitis.

Conclusions:

  • Atorvastatin may be a potential cause of acute pancreatitis.
  • The mechanism is unclear but may be a class effect of HMG CoA reductase inhibitors.
  • Further research is needed to establish a definitive causal relationship.