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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Positron emission tomography: An overview.

A K Shukla1, Utham Kumar

  • 1Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Journal of Medical Physics
|January 6, 2011
PubMed
Summary
This summary is machine-generated.

Positron Emission Tomography (PET) imaging leverages increased glucose metabolism in cancer cells using fluorodeoxyglucose (FDG). Technological advancements in PET scanners and cyclotrons enhance diagnostic capabilities across various cancers and stem cell research.

Keywords:
Bismuth germinate (BGO)Flurodeoxyglucose (FDG)Lutetium oxyorthosilicate (LSO)Positron emission tomography

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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Biochemistry

Background:

  • Tumor cells exhibit significantly higher glucose utilization compared to normal cells.
  • This metabolic difference is exploited in Positron Emission Tomography (PET) imaging, primarily using fluorodeoxyglucose (FDG).

Purpose of the Study:

  • To highlight the technological advancements in PET systems and radiopharmaceutical production.
  • To outline the diverse applications of PET imaging in oncology.
  • To underscore the potential of PET in molecular diagnostics and future research.

Main Methods:

  • Utilizing enhanced glucose uptake in tumor cells for detection.
  • Advancements in PET (CT) systems for fused imaging and attenuation correction.
  • Development of self-shielded cyclotrons for in-house radiopharmaceutical production.

Main Results:

  • PET imaging is a valuable tool for diagnosing pulmonary, colorectal, breast, lymphoma, head & neck, bone, ovarian, and GI cancers.
  • Technological refinements have improved PET system accuracy and radiopharmaceutical availability.
  • PET provides insights into molecular-level biological and physiological changes.

Conclusions:

  • PET imaging, particularly with FDG, is a powerful diagnostic tool in oncology.
  • Ongoing technological progress in PET and radiotracers expands its clinical utility.
  • PET holds significant promise for future applications, including stem cell research.