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Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture

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Electroconvulsive therapy in Lorazepam non-responsive catatonia.

K Girish¹, Neeraj S Gill

¹GIRISH K. MD, Senior Resident, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029.

Indian Journal of Psychiatry

|January 6, 2011

Summary

Electroconvulsive therapy (ECT) showed superior efficacy compared to risperidone in treating lorazepam-non-responsive catatonia. This randomized trial confirms ECT

Keywords:

Electroconvulsive therapy catatonia risperidone

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Published on: August 15, 2017

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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

Area of Science:

Psychiatry
Neurology
Clinical Medicine

Background:

Catatonia is a neuropsychiatric syndrome characterized by motor abnormalities.
Lorazepam is a common first-line treatment, but some patients do not respond.
Alternative treatments are needed for lorazepam-non-responsive catatonia.

Purpose of the Study:

To compare the efficacy of electroconvulsive therapy (ECT) versus risperidone in patients with catatonia unresponsive to lorazepam.
To evaluate treatment outcomes using the Bush-Francis Catatonia Rating Scale (BFCRS).

Main Methods:

A double-blind, randomized trial involving 18 inpatients with non-affective catatonia.
Participants were randomized to receive either true ECT or sham ECT combined with risperidone.
BFCRS scores were assessed twice weekly over three weeks.

Main Results:

Both treatment groups showed a marked reduction in catatonic symptoms.
Electroconvulsive therapy (ECT) resulted in a significantly greater improvement in BFCRS scores compared to risperidone (p=0.035).
Shorter illness duration correlated with better treatment response.

Conclusions:

Electroconvulsive therapy (ECT) demonstrates superior clinical efficacy over risperidone for treating lorazepam-non-responsive catatonia.
This randomized clinical trial supports the use of ECT as a primary treatment for refractory catatonia.