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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Olanzapine induced mania: a case report.

B S Chavan¹, Ajeet Sidana, Gurvinder Pal Singh

¹B.S.CHAVAN, M.D., Professor & Head, Psychiatry, Govt Medical College & Hospital, Block-B, Level-IV, Sector-32, Chandigarh-160047.

Indian Journal of Psychiatry

|January 6, 2011

Summary

This case study highlights rare olanzapine-induced mania and dependence in a schizophrenia patient. Clinicians must monitor for mood changes and olanzapine abuse during treatment.

Keywords:

Abuse Mania Olanzapine

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Area of Science:

Psychiatry
Pharmacology

Background:

Paranoid schizophrenia requires long-term antipsychotic treatment.
Olanzapine is a common atypical antipsychotic used for schizophrenia.
Atypical antipsychotics can have various side effects, including mood disturbances.

Purpose of the Study:

To report a rare case of olanzapine-induced mania.
To highlight the potential for olanzapine abuse and dependence.
To emphasize the need for vigilant monitoring during olanzapine therapy.

Main Methods:

Case report of a 35-year-old male with paranoid schizophrenia.
Review of patient's response to olanzapine therapy (up to 30mg/day).
Assessment of manic symptoms and criteria for dependence syndrome (ICD-10).

Main Results:

Patient developed manic symptoms during olanzapine treatment.
Patient exhibited criteria for dependence syndrome, indicating olanzapine abuse.
Conventional antipsychotics were ineffective for this patient.

Conclusions:

Olanzapine can induce mania and dependence, a rare but significant adverse effect.
Clinicians must be vigilant for mood changes and substance abuse risk in patients on olanzapine.
Careful patient monitoring is crucial to manage potential olanzapine-related complications.