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A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices.
Sowmya Salian1, Srinath Thakur, Sudhindra Kulkarni
1Department of Periodontics and Implantology, SDM College of Dental Sciences and Hospital, Dharwad, India.
The Journal of Clinical Dentistry
|January 7, 2011
Summary
NovaMin dentifrice offers superior relief for dentin hypersensitivity by occluding tubules, outperforming potassium nitrate and non-desensitizing options. This four-week study confirms its efficacy and safety.
Area of Science:
- Dentistry
- Biomaterials Science
- Clinical Research
Background:
- Dentin hypersensitivity is a common clinical condition.
- Existing treatments include potassium nitrate and tubule occluding agents.
- NovaMin is a calcium sodium phosphosilicate biomaterial.
Purpose of the Study:
- To compare the in vivo efficacy and safety of NovaMin and potassium nitrate dentifrices for dentin hypersensitivity.
- To evaluate tubule occlusion potential of the test dentifrices in vitro.
- To assess the clinical outcomes in a South Indian population.
Main Methods:
- A four-week, double-blind, randomized, controlled clinical trial.
- Thirty volunteers with dentin hypersensitivity were recruited.
- Evaluations included tactile, air blast, and cold water sensitivity tests.
Main Results:
- NovaMin and potassium nitrate dentifrices significantly reduced hypersensitivity compared to baseline.
- NovaMin demonstrated statistically greater hypersensitivity reduction than potassium nitrate and control at 2 and 4 weeks.
- In vitro, NovaMin occluded dentin tubules, while potassium nitrate and control did not.
Conclusions:
- NovaMin dentifrice provides rapid and superior relief from dentin hypersensitivity.
- NovaMin effectively occludes dentin tubules, contributing to its desensitizing effect.
- All tested dentifrices, including NovaMin and potassium nitrate, were well-tolerated.