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Updated: Jun 5, 2026

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

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Published on: October 26, 2016

Polymers for drug eluting stents.

Ted Parker¹, Vipul Davé, Robert Falotico

¹Cordis Corporation Warren NJ, USA. Tparker1@its.jnj.com

Current Pharmaceutical Design

|January 7, 2011

Summary

Drug-eluting stents (DES) utilize polymers to control drug release for vascular tissue. Newer bioabsorbable polymers offer a promising alternative, degrading over time to leave a bare metal stent.

Area of Science:

Biomaterials Science
Cardiovascular Engineering
Polymer Chemistry

Background:

Drug-eluting stents (DES) are crucial in treating coronary artery disease.
Current DES employ biostable polymers to bind and control drug elution from metallic scaffolds.
These polymers are critical for stent performance and vascular tissue interaction.

Purpose of the Study:

To review the essential requirements for polymers used in drug-eluting stents.
To analyze the characteristics of currently marketed DES and their polymer coatings.
To explore the potential of next-generation bioabsorbable polymers in DES technology.

Main Methods:

Review of polymer properties, stability, drug compatibility, biocompatibility, and drug release control.

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In-depth analysis of polymer structure, coating design, drug-polymer morphology, and elution profiles of four marketed DES.

Examination of bioabsorbable polymer composition, degradation, and drug release kinetics in new DES platforms.

Main Results:

Key polymer requirements for DES include physical properties, stability, drug compatibility, biocompatibility, and controlled release.
Detailed analysis of four major DES (CYPHER, Taxus, XIENCE V/Promus, Endeavor Resolute) reveals diverse polymer strategies.
Emerging bioabsorbable polymers, like those in the NEVO stent, show potential for improved long-term outcomes by degrading over time.

Conclusions:

Polymers are integral to DES function, dictating drug delivery and vascular response.
Understanding polymer-drug interactions and degradation is vital for optimizing DES performance.
Bioabsorbable polymers represent a significant advancement, potentially leading to stents that leave no permanent foreign material in the vasculature.